Reggie "Sweet" Johnson began his pro career in 1984 and won the USBA Middleweight Title in 1990. Johnson failed in his first attempt at a world title, dropping a close split decision to James Toney in June of 1991. On April 22, 1992, Johnson won the vacant WBA Middleweight Title in East Rutherford, New Jersey, by way of a majority decision over Irishman, Steve Collins. Johnson would successfully defend the title three times before finally losing it to John David Jackson in Buenos Aires, Argentina.

Following two more unsuccessful attempts at the WBA Middleweight title, Johnson eventually moved up to the Light Heavyweight division. On February 6, 1998, at the Mohegan Sun Casino in Connecticut, Johnson knocked out reigning IBF Light Heavyweight champ William Guthrie to win his second world title. He would defend it twice before losing a unification match with Roy Jones Jr. in June of 1999.  Reggie last fought in August, 2005 when he knocked out Fred Moore in Marksville, LA.